Novel muramyl peptide derivative


NEW MATERIAL:A compound expressed by formula I (Ala is alanine; R is H, alkyl, or aralkyl; n is an integer 1-6; A1 and A2 are H or 2-30C fatty acid residue). EXAMPLE:N<epsilon>-(6-O-Stearoyl-N-acetylmuramyl-alanyl-D-isoglutaminy l)-lysine. USE:A preventing and treating agent for microbial infection and an antitumor agent. PREPARATION:The protecting group (Z) in a compound expressed by formula II(Z is a protecting group of the amino group) is eliminated, and if necessary the resultant compound is then condensed with an active substance of a compound expressed by the formula A3-OH (A3 has the same meaning as A1 and A2).




Download Full PDF Version (Non-Commercial Use)

Patent Citations (5)

    Publication numberPublication dateAssigneeTitle
    JP-S5519236-AFebruary 09, 1980Dai Ichi Seiyaku Co LtdMuramyl dipeptide derivative
    JP-S5528932-AFebruary 29, 1980Dai Ichi Seiyaku Co LtdNovel muramyldipeptide derivative
    JP-S5528933-AFebruary 29, 1980Dai Ichi Seiyaku Co LtdMuramyldipeptide dimer
    JP-S5618996-AFebruary 23, 1981Dai Ichi Seiyaku Co LtdMuramyldipeptide derivative
    JP-S5649396-AMay 02, 1981Dai Ichi Seiyaku Co LtdNovel muramyldipeptide derivative

NO-Patent Citations (0)


Cited By (0)

    Publication numberPublication dateAssigneeTitle